I just bought this game and am having the same issues on my Mac. I enjoyed going through all of the scripted tutorials and could live with just doing a force quit after, but now I am trying to do a campaign and can not progress past the first week.
Are you on the same Mac OS version as the OP?
What it reads like (and I am no Mac expert for certain) is the game can't save its settings. On a PC, that is located at:
That likely helps no one but if you know where your game data is saved (Ill see if I can find out myself later), it would be prudent to rename the folder it is in, rerun the game, and see if it's recreated \ if the game runs then.
Stardock Product Lifecycle Manager