A minor update, Patent lab has become relatively hot lately, especially in the meta I play in. The reason being that nanotech being the best ****ing patent in our games, since all the prices are being messed around with hacker array and market shinanigans, there are now quite many people going for a fast level 2 patent lab. Teleportation, while still being very good, is just too expensive, and in the good/price ratio falls just so behind. Other hot items are smart machines and carbon scrubbing , also+100% energy adjacency is some situations, but mostly early game. Teleportation is still grabbed as a luxury patent at some point, but usually you just want to play smart with placing your claims and buildings.
One combo I've also seen is +100% efficiency of pleasure domes along with -50% power consumption.
Engineering lab is however quite less used, and very often when I even produce it, it just doesn't feel impactful enough as upgrading anything to high levels takes so long that by then the situation has changed completely, and upgrading only one levell makes you wonder why you just don't use it for another building(getting nanotech beats engineering lab quite a lot) The only reasons I've seen is upgrading water in a water light map, and upgrading oxygen since it is really hard to produce.
I know I said before that I had used engineering lab successfully, but the meta just changes, and in the current games I play all markets are being consumed so fast for the engineering lab to be of much use. However it is still useful if you are able to predict shifts or are controlling them yourself, also an upgraded 3 cluster attracts much less aggro than a none upgraded 4 cluster.
And one of the key aspects is, that if you got away with patent lab or engineering lab and moved them to HQ, then you couldn't sabotage them, which I think can be a bad idea... it basically makes expansive the best researcher as they upgrade their HQ the fastest so they could easily grab the best patents without a way for others to stop them.