I basically set up the game to be unloseable. Played a campaign against Applicant AIs, and on the last day just monopolized aluminum, let it hit 1000 per unit, and tanked everything else, basically making it too costly for the computer to expand. Managed to get 5 offworld markets with +100% speed, then set up my auto sell on a few of the resources that Sam wasn't creating at an auto-sell rate that was just below the demand. After she was set up, realized she wasn't producing power, so I manipulated that to the point where she had to shut off all her buildings.
After that, just let the game run. I understand this really isn't how the game is meant to be played; the overflow issue aside, the UI isn't built for this kind of punishment either - at $1billion you lose visibility to some of your numbers in the upper left corner, and the longer you play the slower the system gets. I was running FRAPS so I could log video of the moment the integer overflow error happened, and that shows your framerate in the upper left corner, which after so many sols my computer was running at 2 fps.
There's also a weird issue with the computer incurring so much debt - there's some protection from them getting a certain value (I can't remember what it is - 1 million maybe?) and when they go over that they inexplicably lose debt. That's fine... but there's an odd tie in to the Financial Instruments patent in which I lost money every time that happened.
All that combined means that the computer will eventually win though, because once you hit the integer overflow, your stock price tanks and the computer can begin to buy you out no matter how bad they've played.