I usually play 4x games for the epic. I was actually really excited about potentially being able to play with 100 civs, till I realised maybe my computer or any computer outside the Pentagon can't run it
It is a sure bet that 100 players will require more than the specified "minimum" or "recommended" amount of RAM. At this point, how much is a huge question mark.
Of course it would be more than the specified minimum. You don't need to be able to run 100 civs to run 5 or 6.