In most cases, there's never been problems with moving profiles off the same disk. In fact, it's included in the Win2012 server performance guide. It's generally been pretty standard for years as long as you do it properly which is generally through the install process. To find your users profiles, all Windows does is check HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList\ and pull the user profile location.
If I blamed anything, I would probably be concerned about these: TuneUp Utilities, and Glary Utilities.
TuneUp Live Optimization:
Detection: Live Optimization detects programs that you’re not actively using but that are taking up most of your CPUs power.
Optimization: If a process is taking up too much CPU resources, Live Optimization 2.0 automatically balances resources more effectively. Programs that you’re actively using are now much faster again.
Some programs take up CPU resources for a damned good reason. How can this thing possibly know which?
TuneUp Turbo Mode:
Cause: Windows® keeps on running dozens of features, services, processes and scheduled tasks running in the background that you really don’t need. Unfortunately, they’re still in the habit of consuming way too much CPU power and RAM resources, which has a negative impact on performance.
Solution: Our Turbo Mode of TuneUp Utilities 2014 turns off more than 70 invisible features in Windows® 8, Windows® 7, and Windows® XP to boost PC performance. It’s simply the best tool out there for serious users who need above-average performance when designing, video editing, gaming, or programming.
70 Features? That's more than all the services Windows runs combined, naturally no list can be found to say what it's actually doing.
TuneUp 1 Click and Automatic Maintainence:
Clean registry: Solves registry problems and deletes dead keys or values such as startup entries that a 3rd party application forgot to delete, which could lead to problems during startup. It also gets rid of invalid file type pointers and orphaned entries within the list of installed applications which could lead to problems when installing or uninstalling applications. With our 2014 version, the registry is being cleaned up even faster than before.
Optimize startup and shutdown: TuneUp Utilities 2014 stops the startup of applications that are not needed immediately upon system startup:
In general, don't screw with the registry and if you do, use CCleaner and only if you know what you're doing. This thing will delete settings from programs and cause all sorts of ill effects. The best practice is to run the analyzer and then selectively delete what you know is safe.
TuneUp Program Deactivator:
Solution: TuneUp Utilities 2014 sports the best solution for this program, without you having to uninstall programs or sacrifice anything! TuneUp Program Deactivator turns off programs by pausing their background activity when they’re not actively running.
TuneUp Program Deactivator™ works as follows:
Disables programs including all resource-hungry components
Re-enables programs on demand so users can continue using them
Turns programs off, once users don’t need them anymore
TuneUp Program Deactivator is fully integrated into Live Optimization 2.0 – it allows you to turn off resource hogs easier than before
This one to be honest just screms "screw me up." Just because a program is idle at some time doesn't mean it isn't doing something since it could be awaiting events. Automatically disabling programs using resource without knowing what they are....don't even need to address that one.
Beautify Windows® with TuneUp Styler
Tired of the same old Windows® look? Then how about giving Windows® 7, Windows Vista® and Windows® XP a more translucent, “glowing” interface, or a cool, futuristic look with TuneUp Utilities 2014*? TuneUp Styler replaces all the visual elements on your PC easily, safely, and exactly the way you want them.
Visual Styles
TuneUp Styler allows you to quickly switch visual styles, a large number of which can be found on our TuneUp Styler website. You can also head over to www.deviantart.com and check out the “Customization\Skins & Themes\Windows 7 Utilities or Windows® Utilities” library with dozens of styles to choose from.
Yeah this one is great. WindowBlinds is a great app so surely 2 visual stylers should be twice as great!
You should toss this one considering there's tons of papers on why they cause far more harm then good including crashing programs, killing your registry, or just outright do nothing. Screwing around with the settings that WindowBlinds already adjusts is probably the worst thing I can think of out of all of them. Any one of those could be messing with things and running Glary Utilities 3 which does the same thing effectively probably is just throwing dynamite onto an open flame. Keep CCleaner and *maybe* Glary around as CCleaner is the best of them and actually has a beneficial use; I don't see people crying about Glary breaking their computer but messing with the start-up could and you don't have that many start-up apps that need to be adjusted in order so is likely just causing problems.
General rule of thumb:
Don't let programs automatically decide to turn them on or off or change their priorities since they haven't a clue about their use.
Speed-Up programs more often than not just break things and these Start-Up "optimizes" are again just making decisions about apps they don't know anything about so its no surprise its not consistent if they're constantly messing with the start-up order or delaying things.
Stacking on shell extensions you should generally avoid as they make Explorer more unstable. Stacking extensions that are all screwing around with visual settings and Aero sounds like a disaster to be honest. Your Explorer hanging is probably the result of WB and this one fighting over dominance.
If you're running 2 of these at once, you're doubling the system costs and causing god knows what else. I hope you have one disabled from active use at least.
It seems TuneUp has drivers embedded into the OS so you'll likely have to uninstall it just to test being without it. Autoruns is able to disable parts but is best if you know what to look for since messing with the drivers section otherwise can stop system booting. I suggest keeping at least autoruns around but the entire SysInternals suite is extremely helpful as a whole. These are all Microsoft sanctioned programs from the actual engineers that know the internals of the operating system (hence "sysinternals"). There's also the possibility that the "tweaks" these programs do to the registry may need to be reversed manually to help, If it comes to that, I'll show you how.