After placed the HQ, build a water pump, then click on HQ and move your cursor on the water pump (that comes up a water pump info) doing nothing (or click-in on it), you will see the memory usage increasing at about 1MB/s or 2MB/s and ending crash.
It rarely happens in one try at start, but along of the game process it happens somehow randomly (like after in-game day two or day three), (when memory usage oversteps 1GB).
After that, even holding your cursor on the HQ does the same thing too(sometimes you need to click on HQ). This happened to me on Scientific tutorial and on Quick Game (all kinds of HQ).
Doesn't matter if the game is paused or not.
When it crashes? According to this post: https://forums.offworldgame.com/461761/page/1/ The game will crash filling 3.69GB of memory, it doesn't releases the RAM space, it remains still or it increases.
I assume this should explain some random crashes issues, like related "Crashing to desktop after about an hour of play", "Late period game crash".
Ver0.0.4853.